Go to Top

Immunobullous diseases treatments

Immunobullous Diseases

Immunobullous diseases are severe, blistering morbidities of the skin and sometimes the mucous membrane surfaces of the body. As the name suggests, it is a kind of autoimmune disease in which the body’s immune system turns against the organism it should actually protect. In this case in particular, the skin’s connecting proteins are attacked by the faulty autoantibodies. For immunobullous diseases treatments require complex, ongoing and multiple therapies to control the condition, otherwise it can even turn to life threatening.

Types of Immunobullous Diseases

Bullous Pemphigoid

When autoantibodies turn against the proteins connecting the dermis and the epidermis, the autoimmunity manifests in sore, itchy blisters that can appear anywhere in the skin. Patients experience quite unpredictable periods of remission and relapse, and if not given attention, the blisters can cause bad scarring.

Mucous Membrane Pemphigoid

This type causes blistering in any mucous surface of the body, including mouth, nose, esophagus, or anus, all of which areas are prone to tissue damage and scarring. When it comes to immunobullous diseases, treatments must be started the soonest possible to avoid these complications.


In pemphigus the autoantibodies attack the epidermal cell connecting proteins, causing painful blisters in the skin and the mouth. It can be further subdivided into three categories:

Pemphigus follaceous – it is similar to the crusty, reddish looks of eczema and mostly appears on hairy surfaces, such as the scalp, face and chest.

Pemphigus vulgaris – commonly affects in the inside lining of the month

Paraneoplastic Pemphigus – the blisters appear along the respiratory tract which can be fatal if not treated properly.

Treatment Options

In most immunobullous diseases treatments are administered in forms of topical or oral corticosteroids and in severe cases immunosuppresssants (such as cyclophospahmide, azathioprine) to slow down immune activity. To prevent infection and help healing, proper wound care should essentially complement medication. Prednisone and drapsine are two FDA approved drugs that have been used with considerable success in immunobullous diseases treatments.